Hogan, Jeff Hogan

Vaccine dev for prevention of PCP and COPD, RSV infection, COPD; Immune Activation
and Aging, PAH; Immune-mediated mechanisms of pathogenesis, Type 2 diabetes and
metabolic syndrome, therapeutic testing; chronic immune activation/inflammation.
Human antibody-mediated immunity to inform next-generation
vaccine development; focus on immunity to major viral, bacterial,
and fungal human pathogens using multidisciplinary approaches in
immunology, structural biology,and biochemistry to study
antibody-antigen interactions at the molecular level.
Interactions between microbial pathogens and host immunity in the
mouse model using bacteria that naturally infect mice and
closely related strains that are important human pathogens.
Disease intervention strategies for important human pathogens and emerging infectious diseases of zoonotic origin;
mechanisms of immunity; virus-host interface.
Characterizing the assembly of bacterial surface structures, Development of vaccines for viral
and bacterial pathogens, Systems approaches to understanding microbial diseases
Mechanisms of immune activation by carbohydrate antigens; design and development
of knowledge-based vaccines and therapeutics against pathogens and cancers.
Website
Antibiotic & antiviral drug discovery, assay development, enzymology,
and structural biology, regulation of innate immune responses.